Given its high frequency it is not surprising that

2019-08-21

Given its high frequency, it is not surprising that different strategies have been developed to restore the sensitivity of EGFR T790M-mutant CX-4945 to EGFR inhibition.

As one of the two receptors for the primordial

2019-08-20

As one of the two receptors for the primordial chemokine CXCL12, ACKR3 exists in jawless fish (Bajoghli, 2013, Nomiyama et al., 2011, Venkatesh et al., 2014).

To elucidate the potential mechanism underlying osteosarcoma

2019-08-19

To elucidate the potential mechanism underlying osteosarcoma cell growth decrease by CDK4 inhibition, flow cytometry analysis was used to determine TBTA and apoptosis in human osteosarcoma cells after palbociclib treatment.

Introduction Mycobacterium leprae the causative agent of lep

2019-08-17

Introduction Mycobacterium leprae, the causative agent of leprosy, affects skin, peripheral nerves and upper respiratory tract [1].

br Results and discussion br Conclusion We have

2019-08-16

Results and discussion Conclusion We have constructed a series of potent and greatly selective DPP-4 inhibitors with pyrazolo[1,5-a]pyrimidin-7(4H)-one core surrogates.

br Materials and Methods br Results br Discussion

2019-08-15

Discussion ROS generated by SFN target many signaling pathways involved in initiating cancer cell death (Sestili and Fimognari, 2015).

The occurrence of three Ag NORs per

2019-08-14

The occurrence of three Ag-NORs per metaphase and/or a maximum of three nucleoli per nucleus in most of the varieties may be explained by chromosomal rearrangements or unequal crossing-over events that induce the deletion of the fourth active rDNA loci. Also, the chromosome pair that showed less intense 45S rDNA loci after FISH may correspond to a reduced number of copies of rRNA genes hampering their accurate detection by both silver staining and FISH techniques.

Several eukaryotic E enzymes including BRE RNF and RAD have

2019-08-13

Several eukaryotic E3 enzymes, including BRE1 [49], RNF8 [50], and RAD18 [24], [51], have been reported to partner with UBE2B in the ubiquitination of various targets.

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2018-07-29