• br GSNOR regulates SA synthesis and SA signalling The

  2021-12-30

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic KU14R (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistance, le

• Cichlasoma dimerus as most teleost fish species present neur

  2021-12-30

  

  Cichlasoma dimerus, as most teleost fish species, present neurons expressing GnRH3 (Pandolfi et al., 2005). As in most ion channel species, the neurons expressing GnRH3 are mainly located in the NOR, although few neurons were detected in the olfactory bulb, ventral telencephalon and the POA (Gonzále

• lxr agonist Recently higher grade varicoceles have been repo

  2021-12-30

  

  Recently, higher-grade varicoceles have been reported to be associated with higher nocturia levels [20], and we observed an interesting phenomenon in which the urine volume/water intake ratio dramatically increased in the rat model of experimental left varicocele (ELV); the decreases in hypothalamic

• br Advanced Glycation Endproducts As

  2021-12-30

  

  Advanced Glycation Endproducts As glucose levels rise within sensory neurons as a result of hyperglycemia, normal metabolic pathways become overwhelmed and excess glucose is shunted into other ancillary pathways that, under these conditions, become damaging. One consequence of hyperglycemia is th

• br Introduction Glycoproteins represent a staggeringly

  2021-12-30

  

  Introduction Glycoproteins represent a staggeringly small fraction of proteins analyzed by high-resolution techniques despite high concentrations at the cell surface and critical roles in many human diseases. Though one-half or more of all human proteins are predicted to contain a carbohydrate ch

• Studies dealing with the effects of ischemia

  2021-12-30

  

  Studies dealing with the effects of ischemia on EAATs have been previously reported, but some discrepancies in literature appear between them probably as a consequence of the different models, species, time of reperfusion after ischemia and age of the animals. Thus, in human, Spectinomycin hydrochlo

• br Introduction As is now well known obesity

  2021-12-30

  

  Introduction As is now well known, obesity is major risk factor for various diseases such as nonalcoholic fatty liver disease, cardiovascular disease, some cancers (McWilliams and Petersen, 2009), type-2 diabetes mellitus (Jakobsen et al., 2007), and hypertension (Aneja et al., 2004), among other

• Acknowledgments br Introduction Type diabetes

  2021-12-30

  

  Acknowledgments Introduction Type 2 diabetes mellitus (T2DM) is caused by relative insulin deficiency or insulin resistance in peripheral tissues. The clinical management of T2DM is achieved by controlling blood glucose levels. Current therapies available for treatment of T2DM include biguanides

• The mechanism by which Piezo acts in

  2021-12-30

  

  The mechanism by which Piezo1 acts in the regulation of RBC volume is not firmly established. Its curved structure implies that it is activated by an increase in membrane tension (11), a mechanism indicated by electrophysiological measurements (16). However, the RBC membrane mechanics at its physiol

• Studies regarding secretase nowadays aim at elucidating how

  2021-12-29

  

  Studies regarding γ-secretase nowadays aim at elucidating how APP is recognized and recruited. It has been suggested based on coarse-grained molecular simulation that the recognition and recruitment of substrate can occur on an extended surface covering PS1's TM2/6/9 domains and PAL motif [15]. Tran

• Despite the importance of intratumor phenotypic heterogeneit

  2021-12-29

  

  Despite the importance of intratumor phenotypic heterogeneity for tumor progression and therapy resistance (Marusyk et al., 2012, Marusyk and Polyak, 2010), our understanding of regulators of this process and our ability to modulate them are very limited. Recent advances in genomic sequencing and si

• While reduced protein synthesis provides a model to explain

  2021-12-29

  

  While reduced protein synthesis provides a model to explain the long-term memory defects of kdm5 and kdm5 flies, new translation is not required for short-term memories. The chronic reduction in translation observed in mutant fly strains may, however, lower the levels of proteins necessary for short

• TAPI-1 Histamine functions as a key neurotransmitter in mult

  2021-12-29

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, histamine is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathway

• Over recent decades there were

  2021-12-29

  

  Over recent decades, there were three breakthroughs of high intensity heavy-ion acceleration [6]. The first is the invention of radio frequency quadrupole (RFQ) type accelerator, which could accelerate more than dozens of milli-ampere ion beams and is a good solution to space-charge-effect of heavy-

• Because of the commercial availability of some acetamide phe

  2021-12-29

  

  Because of the commercial availability of some acetamide phenol starting materials, a few acetamide final products (such as and , ) were directly synthesized via a Mitsunobu reaction with chloropyrimidine piperidinyl cyclopropyl alcohol . The 3-pyridinyl analogue was synthesized by a nucleophilic

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