• The most likely explanation for the species differences

  2022-12-06

  

  The most likely explanation for the species differences in aromatase distribution and the unique Tosedostat distribution in humans is the unique location, size and highly elaborate organization of the human aromatase gene (e.g. Bulun et al., 2003). The human Cyp19 is a large gene located on chromos

• Once apoptosis has been initiated the HMGA proteins themselv

  2022-12-05

  

  Once apoptosis has been initiated the HMGA proteins themselves undergo marked changes in both the types and extent of their post-translational modifications (PTMs; review in [149,175]), some of which are likely correlated with alterations in chromatin structure. For example, the early stages of apop

• Once apoptosis has been initiated the HMGA proteins themselv

  2022-12-05

  

  Once apoptosis has been initiated the HMGA proteins themselves undergo marked changes in both the types and extent of their post-translational modifications (PTMs; review in [149,175]), some of which are likely correlated with alterations in chromatin structure. For example, the early stages of apop

• br Concluding Remarks Despite major advances in

  2022-12-05

  

  Concluding Remarks Despite major advances in the development of antibody and small-molecule tumor angiogenesis inhibitors, therapy resistance, both innate and acquired, continues to limit further survival improvements for patients with cancer. Preclinical models of localized primary tumors and me

• br Material and methods br Results br Discussion Neurotransm

  2022-12-02

  

  Material and methods Results Discussion Neurotransmitters pathways within vertebrates, including fish, are well conserved (Kreke and Dietrich, 2008, Valenti et al., 2012). Therefore psycopharmaceuticals that are design to act on these pathways in mammals, will possibly interact with the sam

• Role of APPL in endosomal signaling pathways

  2022-12-02

  

  Role of APPL in endosomal signaling pathways Endosomes consist of distinct membrane subdomains within individual organelles and assist in the translation of extracellular stimuli via cytoplasmic transduction cascades to the nucleus [3], [74]. Endosomal abnormalities are associated with the pathogen

• br Introduction S http www

  2022-12-02

  

  Introduction Systemic lupus erythematosus (SLE) is a group of systemic autoimmune disorders characterized by anti-nuclear dcp cas receptor (ANA), rashes and photosensitivity, joint inflammation, nephritis, and other clinical criteria. SLE develops through the breakdown of three major checkpoints

• BMH-21 AXL is a member of the

  2022-12-02

  

  AXL is a member of the TAM (Tyro3, Axl, Mer) family of receptor tyrosine kinases (RTKs) [4]. Elevated AXL expression could promote oncogenic processes such as cell growth, migration, invasion, and epithelial-to-mesenchymal transition (EMT), which substantially contribute to tumor progression and poo

• br Introduction Stroke is a devastating condition that cause

  2022-12-02

  

  Introduction Stroke is a devastating condition that causes cognitive and motor dysfunction, neurodegenerative diseases and even acute death, and is a leading cause of mortality and morbidity worldwide (Chen et al., 2014a, Wang et al., 2016). Thus, exploration or identification of novel therapeuti

• Polyphenols like flavonoids have the potential to

  2022-12-02

  

  Polyphenols like flavonoids have the potential to penetrate into lipid bilayers which is vital for enabling protection against oxidation. Rosmarinic LY2409881 is a natural polyphenol antioxidant isolated from Sphaeranthus amaranthoides. Polyphenols can inhibit the propagation of lipid oxidation by

• br Acknowledgements br Introduction Double stranded DNA

  2022-12-02

  

  Acknowledgements Introduction Double-stranded DNA breaks (DSBs) are among the most deleterious DNA lesions that threaten genomic integrity. DSBs are generated not only by exogenous DNA-damaging agents but also by normal cellular processes such as V(D)J recombination, meiosis, and DNA replicati

• Chromatin proteins play important roles

  2022-12-02

  

  Chromatin proteins play important roles in gene expression and DNA repair. The importance of chromatin composition on gene expression is exemplified by X-inactivation, where one of the two X chromosomes in female mammalian STF 31 is transcriptionally silenced by heterochromatin , , , . In the ATR p

• br Introduction Rhamdia quelen jundi Silurifomes Heptapterid

  2022-12-02

  

  Introduction Rhamdia quelen (jundiá, Silurifomes, Heptapteridae) is a neotropical catfish widely distributed in Central and South America (Silfvergrip, 1996). This species shows high potential for the aquaculture industry, due to an elevated growth rate, good carcass yield, and easy reproduction

• Arginases from several species and tissues have

  2022-12-02

  

  Arginases from several species and tissues have been found to be inhibited by amino acids [51]. In the present study, monocarboxyilic amino acids with five or more carbon atoms such as ornithine, lysine, valine, leucine and isoleucine inhibited CL-ARG. The results revealed that as the amino Irinotec

• br Material and methods br Results br

  2022-12-02

  

  Material and methods Results Discussion The present study demonstrates for the first time that Mino selectively induces apoptosis in Jurkat Tianeptine sodium mg via an H2O2 signaling-dependent mechanism. Structurally, Mino is composed of a C10 and C12 phenol group, C12a hydroxyl group, and

14048 records 317/937 page Previous Next First page 上5页 316317318319320 下5页 Last page