• br Results br Discussion Our finding that

  2023-12-05

  

  Results Discussion Our finding that AXL overexpression is significantly associated with poor survival in patients with high-grade serous OC is consistent with previous reports indicating that AXL regulates tumor growth in some cancers, as well as reports showing that AXL activity is involved i

• The molecular mechanisms involved in the

  2023-12-05

  

  The molecular mechanisms involved in the pathogenesis of cholestatic pruritus remain unknown [45], [46]. Indeed, there has been an enormous effort at understanding the etiology of PBC-related pruritus, including work at the cellular and molecular level, but such efforts have not been translated into

• Lower LDL C mediated by variants in

  2023-12-04

  

  Lower LDL-C mediated by variants in the ACL gene is causally associated with the risk of cardiovascular events. Because, genetic variants that mimic the effect of an ACL inhibitor have the same effect on the risk of cardiovascular events per unit change in LDL-C as variants that mimic the effect of

• Several studies have demonstrated that depletion of function

  2023-12-04

  

  Several studies have demonstrated that depletion of functional ATR increases the sensitivity of cancer cells to oncogene-induced replication stress thereby hindering tumour growth and inducing extensive cell death (Gilad et al., 2010, Murga et al., 2011, Schoppy et al., 2012). Importantly, Schoppy e

• It is now well established that the cumulative

  2023-12-04

  

  It is now well established that the cumulative exposure to endogenous estrogens throughout a woman's life, mainly due to her reproductive history, has an impact on the risk of hormone-dependent breast cancer (Lambertini et al., 2016). Prolonged exposure to estrogens in the case of early age at menar

• In our study S aureus activated the TLR signaling pathways

  2023-12-04

  

  In our study, S. aureus activated the TLR signaling pathways of BMECs, thus inducing profibrogenic growth factor expression via NF-κB and AP-1. Since fibrosis is an important pathogenic process in both bovine and human mastitis, further studies on the molecular mechanisms of S. aureus infection are

• nk1 receptor Recent retrospective cohort studies have suppor

  2023-12-04

  

  Recent retrospective cohort studies have supported these preclinical findings in animals indicating the correlation of AR activation with the induction of nk1 receptor carcinogenesis. First, men with prostate cancer who underwent androgen deprivation therapy were shown to have a significantly lower

• Intriguingly androgens may also have an indirect effect

  2023-12-04

  

  Intriguingly androgens may also have an indirect effect on AR gene expression through inhibition of the GATA2 transcription factor gene (He et al., 2014) (Table 1). Using ChIP-seq, GATA2 was found to bind to a regulatory element 5.5 kb upstream of the TSS of the AR gene and enhanced transcription, w

• The chronic induction of skeletal muscle AMPK activity

  2023-12-04

  

  The chronic induction of skeletal muscle AMPK activity is an attractive therapeutic approach for DMD, as it addresses multiple cellular pathways needed for powerful phenotypic plasticity, including activation of the slow oxidative myofiber program, corrective autophagic signaling, as well as regulat

• Synaptic scaling up is induced within primary

  2023-12-04

  

  Synaptic scaling up is induced within primary visual Triptolide (V1) by brief sensory deprivation (Desai et al., 2002; Lambo and Turrigiano, 2013). Several studies have examined the transcriptional changes within extracts of V1 following visual deprivation protocols (Lachance and Chaudhuri, 2004; M

• br Discussion Elevated blood BCAA levels are

  2023-12-04

  

  Discussion Elevated blood BCAA levels are a common feature of a developed pathophysiological state characterized by obesity and IR [4]. It has been suggested that this profile is part of a panel of biomarkers able to predict the onset of more severe complications like diabetes in humans [14]. In

• In the isolated right atrium activation of muscarinic

  2023-12-04

  

  In the isolated right atrium, activation of muscarinic receptors and adenosine receptors may block the generation of action potentials in the sinoatrial node, inducing cardiac arrest (Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5) (Camara et al., 2015, Campbell et al., 1989). Physiologically, this conditio

• Brain biopsy was performed from

  2023-12-04

  

  Brain biopsy was performed from the white matter lesion around the posterior horn of the right lateral ventricle, and revealed inflammatory demyelination, such as myelin loss with relative preservation of axons, astrocytosis immnolabeled by RITA against glial fibrillary acidic protein, infiltration

• MicroRNA miRNA is an abundant group of

  2023-12-04

  

  MicroRNA (miRNA) is an abundant group of small (22-nucleotide) noncoding RNA molecules that directly binds with 3′ untranslated region (UTR) of target messenger RNAs (mRNAs) to regulate gene expression, playing an important role in variety of biological processes including cell proliferation, apopto

• Introduction Myasthenia gravis MG is an autoimmune

  2023-12-04

  

  Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic Coumarin mg receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopathogenesis of MG. E

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