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Although CP has been an important research subject in
2024-01-10
Although CP has been an important research subject in the field of antigen processing and presentation, the mechanisms of presentation of intracellular KC7F2 mg by MHC II received considerably less attention. Interestingly, pioneering work by the Münz laboratory has pointed to an involvement of aut
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A different mechanism has been suggested
2024-01-10
A different mechanism has been suggested for the role of TRX1 in ASK1 regulation based on disulfide bond-mediated ASK1 multimerization and its reduction through the thiol-reductase activity of TRX1 (Nadeau et al., 2007, Nadeau et al., 2009). In this model, oxidative stress induces intermolecular dis
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br Conclusion In conclusion the
2024-01-10
Conclusion In conclusion, the arginase from P. aeruginosa IH2 was purified with electrophoretic homogeneity. Purified enzyme was homo-dimer and showed significant activity and catalytic stability near to the pH of circulating system and temperature of human body. The prolonged serum and proteolyt
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Co is an essential element for life in minute amounts
2024-01-10
Co is an essential element for life in minute amounts [5]. The human adult contains about 1.1mg Co with the daily requirement of 0.1μg/day. Co is a component of vitamin B12. Co induces erythropoietin and blocks iodine uptake by the thyroid, controls the transfer of enzymes like homocysteine methyltr
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To clarify the molecular mechanism
2024-01-10
To clarify the molecular mechanism of maduramicin-induced apoptosis in chicken myocardial cells, the mRNA levels of bcl-2, bax, and cytochrome C, as well as the mRNA levels and activities of caspase-3/8/9 were determined. The mRNA expressions and activities of initiator casapase-9 and executioner ca
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Over expression of the inflammatory
2024-01-10
Over expression of the inflammatory cytokines, MMPs and COX-2 act as an important inducer of chronic inflammation. COX-2 catalyzes the biosynthesis of prostaglandins (PGs), and induced expression was observed in rgd peptide stimulated with pro-inflammatory cytokines or bacterial lipopolysaccharide (
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We report here the case of
2024-01-10
We report here the case of a patient with probable genetic prion disease with a Creutzfeldt-Jakob disease-like phenotype associated with a rare PRNP E196K mutation who initially exhibited atypical clinical manifestations principally characterized by behavioral abnormalities. Case report An 80-ye
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br Concluding Remarks and Future Perspectives Fluorescent an
2024-01-10
Concluding Remarks and Future Perspectives Fluorescent FPH2 synthesis have helped researchers to elucidate antibiotic MOA and off-target interactions, to screen for new antibiotics, to detect antibiotics in the environment, to track antibiotic uptake throughout cells and organisms, and to detect
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br AR expression in breast tissue Although androgenic
2024-01-10
AR expression in breast tissue Although androgenic signalling is chiefly associated with the development and maintenance of primary and secondary male characteristics, especially during puberty when the testes are by far the major source of testosterone, the AR also plays important functions in f
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Go 6983 PGC mediated mitochondrial biogenesis in brown
2024-01-10
PGC-1α-mediated mitochondrial biogenesis in brown fat and endothelial Go 6983 is in part regulated by eNOS and NO [28], [29]. Recent studies indicate that H2S not only augments NO bioavailability and signaling [11], [17], but provides protection against cardiac injury in an eNOS-dependent manner [1
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br Discussion To our knowledge this is the
2024-01-10
Discussion To our knowledge, this is the first case report that demonstrates the presence of a novel T1151K ALK mutation in a patient with disease progression after crizotinib and then ceritinib. As early as 2011, Zhang et al. identified T1151K among other resistance mutations to crizotinib in Ba
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Introduction Inflammasomes are large cytosolic protein compl
2024-01-10
Introduction Inflammasomes are large cytosolic protein complexes with multiple components that trigger a rapid immune response against pathogen-associated molecular pattern Guanethidine Sulfate synthesis (PAMPs) during pathogen infections or damage-associated molecular pattern molecules (DAMPs) du
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Liaohe River situates in the southwestern part of Northeast
2024-01-10
Liaohe River situates in the southwestern part of Northeast China and flows through Liaoning Province. Due to the rapid urbanization and industrialization, Liaohe River has become one of the most polluted rivers in China. Multitudinous organic pollutants that can induce toxicity to organisms such as
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Multiple ASD susceptibility genes converge on cellular pathw
2024-01-09
Multiple ASD susceptibility genes converge on cellular pathways that intersect at the postsynaptic site of glutamatergic synapses (Bourgeron, 2015; Peca & Feng, 2012), the development and maturation of synaptic contacts (Gilman et al., 2011) or synaptic transmission (Li et al., 2014). The majority o
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Because serum ATX activity and plasma
2024-01-09
Because serum ATX activity and V5 peptide LPA are well correlated with liver fibrosis stage histologically, both of these parameters merit consideration as novel markers of fibrosis. However, serum ATX activity may be a more useful test from a clinical laboratory perspective. First, LPA can increase
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